Now that Holmes & Watson is at the Box and On Demand, it got me thinking about the best cinematic duos. That’s probably because the stars of the film (Will Ferrell, who plays Sherlock Holmes, and John C. Reilly, who plays Watson) have paired up before in one of my favorite movies.

Here are 6 movie duos that never let me down.

Talladega Nights In this spoof of the NASCAR scene, Ferrell plays racing great Ricky Bobby, who — together with his best friend Cal Naughton Jr. (Reilly) — is always ready to “shake and bake.” But when Ricky starts losing and Cal ends up with Ricky’s “red-hot smokin’” wife, it spells serious trouble for the ultra-quotable duo. Thankfully, a common enemy in the form of French racer Jean Girard (Sacha Baron Cohen) might provide just the motivation the former friends need to reunite.

21 Jump Street In 2012, Magic Mike came out and confirmed what the masses already knew: that Channing Tatum looked good in his skivvies. But that same year, Tatum also surprised everyone by showing that he could hold his own opposite proven funnymen like Jonah Hill. Together, they were the perfect “opposites attract” type of duo, playing cops who go undercover at a high school that’s suffering from the rise of a new synthetic drug. I continue to be shocked by how much I loved these guys sharing a screen.

Bad BoysA full 25 years (!!!) after this movie came out, the third film in the franchise — Bad Boys for Life — will hit theaters next year. That’s right: Miami narcotics detectives Mike Lowrey (Will Smith) and Marcus Burnett (Martin Lawrence) are coming back. In this first film, they’re charged with trying to figure out if the theft of $100 million in heroin from a police vault was an inside job. This duo had instant chemistry, unforgettable one-liners and huge box office numbers. Bad boys, bad boys, whatcha gonna do (to top the first two movies)?

Thelma & Louise BFFsThelma (Geena Davis) and Louise (Susan Sarandon) were fierce long before being fierce was a thing. This road-trip movie will make you believe that there’s nothing two female friends can’t do, and nothing that could come between them — even Brad Pitt.

Wayne’s World Still the highest-grossing movie based on a Saturday Night Live skit, this early ‘90s goofball comedy about rock fans and public-access show hosts Wayne (Mike Myers) and Garth (Dana Carvey) has experienced something of a pop-culture resurgence thanks to a new generation being introduced to the band Queen by way of Bohemian Rhapsody. That’s because in Wayne’s World, Wayne, Garth and their buddies head-bang to the song in a classic movie-stealing scene. But even greater than their rockstar fantasies is their brotherly bond. Party time … excellent!

Wedding CrashersVince Vaughn and Owen Wilson were each at the top of their respective careers when this movie came out in 2005, so putting them together and letting them riff off of each other was guaranteed comedic gold. In this smash hit, they play divorce mediators who sneak into weddings to meet women. When they set their sights on crashing the US Treasury Secretary’s (Christopher Walken) eldest daughter’s wedding, they meet his two other daughters — played by Rachel McAdams and Isla Fisher — and soon realize they’re finally in over their heads.

Who are your favorite movie duos?

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